Love this stuff! I have chronic fatigue in my legs and ordered this, not expecting any significant effect. There are 2 occasions that demonstrated to me just how good it is. I first applied it to my legs, but not my knees. Another time I was running out, new order not yet arrived, and had only enough for one leg. On both occasions I applied the balm before bed, but was woken by pain (as was usual), but only in the areas that I had not applied the balm. I have also used it to treat a pulled ligament in my knee, with significant reduction in pain after only 2 applications. I use this after exercise and before bed (up to 3 times a day). Would not be without it!